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yvrC [2019-08-26 10:46:38]
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yvrC [2019-08-26 10:46:38]

ABC transporter (binding protein) for cobalamin
Locus
BSU_33180
Isoelectric point
4.93
Molecular weight
34.08 kDa
Protein length
314 aa Sequence Blast
Gene length
945 bp Sequence Blast
Function
uptake of cobalamin
Product
ABC transporter (binding protein)
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Importers → Uptake of cofactors
  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis/ acquisition of cobalamine (B12))
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,403,493 → 3,404,437

    The protein

    Protein family

  • Bacterial solute-binding protein 8 family (according to UniProt)

    • Structure

  • 4M7O (from Staphylococcus epidermidis, 45% identity)

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    yvrC-yvrB-yvrA-yvqK

    Regulatory mechanism

  • B12 riboswitch: termination, upon binding of B12 PubMed, in B12 riboswitch

    • Regulation

  • expression is decreased in the presence of cobalamin (vitamin B12) (B12 riboswitch) PubMed
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    Biological materials

    Mutant

  • MGNA-B045 (yvrC::erm), available at the NBRP B. subtilis, Japan
  • BKE33180 (ΔyvrC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATCTTTTCCTCCTAAA, downstream forward: _UP4_CGTCTGATCGAAGGGGTCGA
  • BKK33180 (ΔyvrC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATCTTTTCCTCCTAAA, downstream forward: _UP4_CGTCTGATCGAAGGGGTCGA

    • References

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